Mary Louise DeSpain was born in Hutchinson, KS to William Ivy Yoakum and Lois Irene Harden. She came to Oklahoma City in 1932 where she attended Bath, Webster and graduated from Northeast High School in 1940. She was a long-time member of Kelham Baptist Church. Mary worked for Dr. Charles Smith and Dr. Robert Outlaw for 24 years as business manager. She was president of the Oklahoma County Medical Assistants Association, and was a member of the American Association of Medical Secretaries and the American College of Medical Group Managers. Mary was appointed the first executive secretary to the Oklahoma District Branch of the American Psychiatric Association as well as to the American College of Psychiatrists. She retired in 1985 and then worked for Dr. Stanley McCampbell for 10 years. Mary was preceded in death by her parents; and 3 brothers, Clarence Wilmoth, Dallas Ezra and Virgil Ralph. She is survived by her sons, Leon DeSpain of Plano, TX and Glen DeSpain and wife Diana of Tuttle, OK; her grandchildren and spouses, Craig DeSpain and wife Sharon of Hudson Oaks, TX, Kevin DeSpain and wife Wendy of Lake Dallas, TX, Amber (DeSpain) and husband Sheldon Lambrecht of Tuttle, OK, Chad DeSpain and wife Lisa of Oklahoma City, Jeremy DeSpain and wife Megan of Edmond, OK; her great-grandchildren, Sydney (DeSpain) and husband Jack Parker of Austin, TX, Bailey (Lambrecht) and husband Connor Litterell of Tuttle, OK, Craig Jr. DeSpain of Hudson Oaks, TX, Madison, Gabriel and Aiden DeSpain of Lake Dallas, TX, Meagan Lambrecht of Tuttle, OK, Charlie Malone and Jacob DeSpain of Edmond, OK, Case, Cori and Coda DeSpain of Oklahoma City; and her great-great-grandchildren, Harper and Kollins Litterell of Tuttle, OK. In her final days, Mary received excellent care from her family, Shirley Mayfield, Debbie Rice and Complete Hospice Services. In lieu of flowers, please consider a contribution to Complete Hospice OKC or the American Cancer Society. A memorial service will be held at Mercer Adams Chapel at 12:00pm on Saturday, July 8, 2023. Interment will follow in Resurrection Memorial Cemetery in Oklahoma City, OK. . Memorial Service Mercer-Adams Chapel Saturday, July 08, 2023 12:00 PM 3925 N. Asbury Bethany, OK 73008